Emerging Green Technologies at CDMOs in Pharma Manufacturing

CDMOs face increasing scientific and operational challenges in implementing greener and more efficient manufacturing processes. Time constraints, cost pressures, and limited development windows often hinder the adoption of innovative approaches at commercial scale. To overcome these limitations, many CDMOs have established platform and enabling technologies that accelerate process development and technology transfer. Examples include peptide synthesis platforms, enzyme evolution and biocatalysis, high-throughput reaction screening, continuous processing, advanced crystallization, N-1 perfusion and enabled formulation technologies. These platforms not only enhance process robustness and scalability but also enable data-driven optimization and improved sustainability metrics. This session will cover all common therapeutic modalities (small molecules, biologics, peptide, oligonucleotides, etc) prevalent in Pharma from experts in the CDMO manufacturing space. Emerging technologies such as digital twins, process analytical technologies (PAT), and AI-assisted modeling are further expanding the toolbox for developing greener and more reliable manufacturing routes. Their integration, however, brings new challenges in data management, validation, and cross-disciplinary collaboration. This session will present case studies and recent advances illustrating how such technologies are being implemented within CDMO environments. Speakers will discuss successes, limitations, and opportunities for broader application highlighting the scientific and technological pathways toward more sustainable, efficient, and flexible manufacturing.

Hanno Erythropel, Ph.D., Yale University

Lars Ratjen

Paul Anastas, Yale University

Peter Licence, The University of Nottingham

Hanno Erythropel, Ph.D., Yale University

Lars Ratjen

Paul Anastas, Yale University

Peter Licence, The University of Nottingham